AMIC®/AMIC®+ Chondro-Gide® Knee

Benefits

With its specially designed bilayer structure, Chondro-Gide® provides a protective environment that fosters the growth of new tissue.

• Bio-derived, bilayer Collagen I/III membrane
• Biocompatible and naturally resorbed
• Easy to handle: supple and tear-resistant
• Can be glued into place
• Compatible with a range of tissue regeneration techniques
• One-step procedure
• Ready for use off the shelf

Clinical Evidence

AMIC® Chondro-Gide® has been shown to be an effective treatment to repair cartilage lesions of all sizes in the knee. Clinical studies show successful treatment using both mini-open and arthroscopic techniques for more than 10 years.

Better Performance than MFx Alone, After 2 Years

In a randomised, controlled 3-arm study of 47 patients in 2 centres, a significant deterioration in results was seen after 2 years following MFx alone (without Chondro-Gide®). Pain and function scores (ICRS and modified Cincinnati scores) remained stable or even improved with AMIC®, whilst pain and function scores for the MFx group decreased.

Arthroscopic or Mini-Arthrotomy — Both Give Equally Good Results

In a retrospective study, Schagemann et al. compared the clinical outcomes of AMIC® Chondro-Gide® procedures performed as arthroscopic or mini-open surgeries, following patients up to 2 years. According to patients’ VAS, Lysholm scores, and KOOS, both surgical approaches yielded equally positive results.

Meta-Analysis of 12 AMIC® Chondro-Gide® Studies Including 375 Patients

A 2019 systematic review and meta-analysis evaluated grade III/IV chondral and osteochondral lesions in the knee with a mean defect size of 4.24 cm² and up to 7 years of follow-up. The use of AMIC® Chondro-Gide® significantly reduced pain and improved function from baseline to follow-up. Results were maintained over more than 5 years, confirming the long-term success of AMIC® Chondro-Gide® in larger (>4 cm²) grade III and IV lesions.

ACI-C and AMIC® Chondro-Gide® Provide Equally Good Results After 2 Years

Fossum et al. (2019) conducted a prospective, randomised, controlled study assessing outcomes of ACI-C and AMIC® in chondral and osteochondral defects of the distal femur and patella. No significant differences were seen between the two techniques at 1 and 2 years. The authors concluded that AMIC® could be considered a clinically equal but less expensive alternative to ACI-C, as AMIC® is a single-step procedure and therefore far less resource-intensive.